The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8,676 newborns by screening of HLA-DR-DQ haplogenotypes at six clinical centers in four countries, and collected longitudinal plasma samples following birth for mass spectrometry metabolomics analysis and ascorbic acid, 25-hydroxyvitamin D (25(OH)D) measurement under a nested case-control design.
Jude Children’s Research Hospital and University of South Florida and University of South Florida and Finnish Institute for Health and Welfare and Lund University and Pacific Northwest Research Institute and University of Colorado Denver and Augusta University and University of Turku and Technical University of Munich and NIDDK/NIH and University of South Florida Qian Li* and Xiang Liu and Jimin Yang and Iris Erlund and Åke Lernmark and William Hagopian and Marian Rewers and Jin-Xiong She and Jorma Toppari and Anette-G Ziegler and Beena Akolkar and Jeffrey Krischer
Longitudinal Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study Statistical Challenges and Breakthroughs in Diabetes and Obesity Research in the Big Data Era